The endocytic receptor megalin binds the iron transporting neutrophil‐gelatinase‐associated lipocalin with high affinity and mediates its cellular uptake
Open Access
- 24 December 2004
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 579 (3), 773-777
- https://doi.org/10.1016/j.febslet.2004.12.031
Abstract
We show here that megalin, a member of the low‐density lipoprotein receptor family expressed in polarized epithelia, binds NGAL with high affinity, as shown by surface plasmon resonance analysis. Fur...Keywords
This publication has 35 references indexed in Scilit:
- Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating ironNature, 2004
- The Neutrophil Lipocalin NGAL Is a Bacteriostatic Agent that Interferes with Siderophore-Mediated Iron AcquisitionMolecular Cell, 2002
- Induction of Apoptosis by a Secreted Lipocalin That is Transcriptionally Regulated by IL-3 DeprivationScience, 2001
- MEGALIN- AND CUBILIN-MEDIATED ENDOCYTOSIS OF PROTEIN-BOUND VITAMINS, LIPIDS, AND HORMONES IN POLARIZED EPITHELIAAnnual Review of Nutrition, 2001
- Molecular Cloning of a Novel Lipocalin-1 Interacting Human Cell Membrane Receptor Using Phage DisplayPublished by Elsevier BV ,2001
- Megalin Knockout Mice as an Animal Model of Low Molecular Weight ProteinuriaThe American Journal of Pathology, 1999
- The Intrinsic Factor-Vitamin B12 Receptor and Target of Teratogenic Antibodies Is a Megalin-binding Peripheral Membrane Protein with Homology to Developmental ProteinsJournal of Biological Chemistry, 1998
- Removal of lactoferrin from plasma is mediated by binding to low density lipoprotein receptor‐related protein/α2‐macroglobulin receptor and transport to endosomesFEBS Letters, 1995
- Studies of the release and turnover of a human neutrophil lipocalinScandinavian Journal of Clinical and Laboratory Investigation, 1995
- Molecular Cloning and Expression of a cDNA Encoding NGAL: A Lipocalin Expressed in Human NeutrophilsBiochemical and Biophysical Research Communications, 1994