The Effects of Vancomycin and β-Lactam Antibiotics on Vancomycin-ResistantStaphylococcus aureus

Abstract

First Sieradzki et al.¹ and then Climo et al.² presented evidence that combinations of vancomycin and β-lactam antibiotics were synergistic in vitro and in vivo against vancomycin-resistant Staphylococcus aureus. We performed population analyses to examine the effectiveness of combinations of vancomycin and β-lactam antibiotics against S. aureus strains with various levels of vancomycin resistance: Mu 3 and Mu 50 ³ (provided by Keiichi Hiramatsu, Juntendo University) and wound isolates Fu 10 and Fu 18, which were recovered from a patient receiving combination therapy with β-lactam antibiotics and vancomycin in our hospital.