Comparison using central core model of renal medulla of the rabbit and rat

Abstract

The central core model of the rabbit medulla predicted concentration gradients and volume flow rates. The handling of urea was not consistent with the scheme proposed by Kokko and Rector. Moreover, the low concentration of urea predicted for the urine suggests an absence in the model of some form of mediated transport for urea in the inner medulla. The central core model of the rat medulla failed to predict results. Substitution of the rabbit thermodynamic parameters into the model for the rat resulted in predictions that more closely resembled what was expected, but were not entirely satisfactory. The implication was that there may be an interspecies difference in the concentration machinery between the rabbit and rat.