Relationship of Native Heparin to Clearing of an Alimentary Liepmia.

Abstract

Studies have been made to determine the effects of native heparin upon the lipemia of cream-fed dogs. Shock due to anaphylaxis or to the injection of certain histamine liberators sometimes caused heparin to appear in the blood of the animals. The presence of native heparin in the blood, however, did not necessarily coincide with clearing of a lipemia; fat clearing might occur during shock either in the presence or in the absence of detectable amts. of native heparin in the blood of dogs. In several expts., the injection of dextran (mol. wt. 75,000) produced marked clearing of a heavy alimentary lipemia in the absence of heparin activity in the blood of dogs. Protamine sulfate caused the return of both visible turbidity of the plasma and of whole blood chylomicron counts to control levels after fat clearing due to shock. This occurred both in the presence and absence of significant blood heparin activity.