Hydrolysis and Absorption of Pantothenate and Its Coenzymes in the Rat Small Intestine
- 1 October 1983
- journal article
- research article
- Published by Elsevier in Journal of Nutrition
- Vol. 113 (10), 2107-2115
- https://doi.org/10.1093/jn/113.10.2107
Abstract
The transport of pantothenate by the rat small intestine occurs by simple diffusion. There was no significant difference in the rate of in the upper, middle or lower sections of the intestine. Coenzyme A was hydrolyzed to pantetheine and pantothenate in the intestinal lumen via the following series of reactions: coenzyme A → phosphopantetheine → pantetheine → pantothenate. Intestinal tissue, which contains high levels of pantetheinase, quickly degrades pantetheine to pantothenate, which is then transported to the blood and thence to other tissues. Tissue distribution patterns of 14C 5 hours after intraluminal administration of 14C-labeled coenzyme A or [14C]pantothenate were similar; approximately 40% of the 14C was present in muscle and 10% in liver.Keywords
This publication has 8 references indexed in Scilit:
- [44] Synthesis of coenzyme A and its biosynthetic intermediates by microbial processesMethods in Enzymology, 1979
- METABOLISM OF PANTETHINE IN THE RATJournal of Nutritional Science and Vitaminology, 1974
- Enzymatic Synthesis of 14C-Labelled Coenzyme A from Pantothenic Acid-l-14C or Adenosine Triphosphate-8-14CRADIOISOTOPES, 1972
- THE ABSORPTION OF BOUND FORMS OF B-GROUP VITAMINS BY RAT INTESTINEQuarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1962
- THE ABSORPTION OF SOME B‐GROUP VITAMINS BY SURVIVING RAT INTESTINE PREPARATIONSQuarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1962
- The substrate specificity and inhibition of alkaline phosphatases of cow's milk and calf intestinal mucosaBiochemical Journal, 1955
- Techniques and Reagents for Paper ChromatographyAnalytical Chemistry, 1951