In vitro Synergistic Activity of Ketoconazole with Trifluoperazine and with Chlorpromazine against Medically Important Yeasts
- 31 December 1987
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 34 (2), 96-100
- https://doi.org/10.1159/000238554
Abstract
Combination of ketoconazole and trifluoperazine or chlorpromazine yielded an in vitro synergistic effect on growth inhibition of Candida albicans, Torulopsis glabrata, Cryptococcus neoformans, Candida parapsilosis and Candida tropicalis. The optimal pH range for the synergistic effects was 7.0–7.6. At pH 5.0 the drug combination was antagonistic. (Application for patent protection has been filed.)Keywords
This publication has 2 references indexed in Scilit:
- Activity of phenothiazines against medically important yeastsAntimicrobial Agents and Chemotherapy, 1987
- Candida albicans resistance to 5-fluorocytosine: frequency of partially resistant strains among clinical isolatesAntimicrobial Agents and Chemotherapy, 1982