Rapid Remodeling of Axonal Arbors in the Visual Cortex
- 18 June 1993
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 260 (5115), 1819-1821
- https://doi.org/10.1126/science.8511592
Abstract
If vision in one eye is blurred or occluded during a critical period in postnatal development, neurons in the visual cortex lose their responses to stimulation through that eye within a few days. Anatomical changes in the nerve terminals that provide input to the visual cortex have previously been observed only after weeks of deprivation, suggesting that synapses become physiologically ineffective before the branches on which they sit are withdrawn. Reconstruction of single geniculocortical axonal arbors in the cat after either brief or prolonged monocular occlusion revealed striking axonal rearrangements in both instances. Rapid withdrawal of the branches of deprived-eye arbors suggests that axonal branches bearing synapses respond quickly to changing patterns of neuronal activity.Keywords
This publication has 30 references indexed in Scilit:
- Synaptic Regulation of Immediate-Early Genes in BrainCold Spring Harbor Symposia on Quantitative Biology, 1990
- Activity-dependent regulation of GABA expression in the visual cortex of adult monkeysNeuron, 1988
- Effects of monocular deprivation on geniculocortical synapses in the catJournal of Comparative Neurology, 1984
- Role of intracortical inhibition in deprivation amblyopia: reversal by microiontophoretic bicucullineBrain Research, 1981
- The axonal arborizations of lateral geniculate neurons in the striate cortex of the catJournal of Comparative Neurology, 1978
- Ocular dominance in layer IV of the cat's visual cortex and the effects of monocular deprivation.The Journal of Physiology, 1978
- Reversal of the physiological effects of monocular deprivation in the kitten's visual cortex.The Journal of Physiology, 1976
- Bicuculline reversal of deprivation amblyopia in the catNature, 1976
- Functional Architecture of Area 17 in Normal and Monocularly Deprived Macaque MonkeysCold Spring Harbor Symposia on Quantitative Biology, 1976
- The period of susceptibility to the physiological effects of unilateral eye closure in kittensThe Journal of Physiology, 1970