Five-Year Follow-up of Cognitive Impairment With No Dementia

Abstract

THE CONCEPT of cognitive impairment with no dementia (CIND), including mild cognitive impairment (MCI), has emerged as an important clinical entity, with a prevalence in elderly people about twice that of all forms of dementia combined.¹ This heterogeneous classification includes people who present with focal abnormalities, lifelong developmental disabilities, or psychiatric illnesses. The subset of people with MCI has been linked to the onset of Alzheimer disease (AD),² but debate continues as to whether MCI is prodromal of AD or all forms of dementia.³ It remains unclear whether impairments not included in MCI may also progress to dementia.