Comparison of Neutralization and Hemagglutination-Inhibition Techniques for Measuring Mumps Antibody
- 1 August 1967
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 125 (4), 1068-1071
- https://doi.org/10.3181/00379727-125-32278
Abstract
Mumps hemagglutinating antigen treated with Tween 80 and ether showed 2- to 4-fold enhancement of hemagglutinating activity of the treated antigen was stable on freezing and on storage for at least 3 months at 4[degree]C. Sera from children following vaccination with Jeryl Lynn strain live mumps virus vaccine or following natural mumps infection nearly always gave higher antibody titers when the Tween-ether treated antigen was used in the HI test than when whole virus antigen was employed. The serum neutralization test, however, was more sensitive than HI technique and was required to detect antibody in specimens with low level of antibody. Comparative titer values of sera obtained by the various test procedures are presented.This publication has 4 references indexed in Scilit:
- Live, Attenuated Mumps-Virus VaccineNew England Journal of Medicine, 1967
- Live, Attenuated Mumps-Virus VaccineNew England Journal of Medicine, 1967
- Live Attenuated Mumps Virus Vaccine. 1. Vaccine DevelopmentExperimental Biology and Medicine, 1966
- Advances in control of viral infections by nonspecific measures and by vaccines, with special reference to live mumps and rubella virus vaccinesClinical Pharmacology & Therapeutics, 1966