Failure to Confirm Cyclic AMP as Second Messenger for Norepinephrine in Rat Cerebellum
- 15 February 1974
- journal article
- book review
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 183 (4125), 663-664
- https://doi.org/10.1126/science.183.4125.663
Abstract
Microiontophoretic applications of adenosine 3',5'-monophosphate (cyclic AMP) to spontaneously active, electrophysiologically identified Purkinje cells of the rat cerebellum failed to mimic the strong depressant action of norepinephrine on the same cells. These findings, in combination with a reevaluation of other studies, cast doubt on the hypothesis that cyclic AMP mediates the depressant actions of norepinephrine in the cerebellum.Keywords
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