UV inducible UV protection and mutation functions on the I group plasmid TP110
- 1 February 1984
- journal article
- research article
- Published by Springer Nature in Molecular Genetics and Genomics
- Vol. 193 (2), 316-321
- https://doi.org/10.1007/bf00330687
Abstract
The UV protection and mutation properties of the I group plasmid TP110 have been investigated. It is demonstrated that the genes responsible for these effects are able to complement the deficiency in umuC36 mutants of E. coli, as are the similar genes carried by the B group plasmid R16. Mu-lac inserts into TP110 have been isolated which abolish the UV protection and mutation functions. Restriction mapping of these inserts locates them within a single region of the genome. A comparison of the restriction sites of this region with the muc region of pKM101 reveals very little similarity. Expression of β-galactosidase in those Mu-lac inserts in which the lacZ gene is fused to the promoter for the protection and mutation functions is inducible by DNA damaging agents, and induction in mutant strains suggests that these genes are under the direct control of the lexA repressor.This publication has 31 references indexed in Scilit:
- Identification of plasmid (pKM101)-coded proteins involved in mutagenesis and UV resistanceNature, 1982
- DNA-damage inducible genes on the I group plasmid TP 110Biochimie, 1982
- A restriction map of the Incl1 plasmid TP110Plasmid, 1982
- The SOS regulatory system of Escherichia coliCell, 1982
- Distribution among incompatibility groups of plasmids that confer UV mutability and UV resistanceMutation Research, 1980
- Control of recA gene RNA in E. coli: Regulatory and signal genesCell, 1980
- A Role for recF in Repair of UV Damage to DNAPublished by Cold Spring Harbor Laboratory ,1979
- DNA synthesis inhibition and the induction of protein X in Escherichia coliJournal of Molecular Biology, 1976
- Increase in frequency of ultraviolet-induced mutation brought about by the colicine factor, colI in Salmonella typhimuriumMutation Research, 1966
- Resistance to the Bactericidal Effect of Ultraviolet Radiatic Conferred on Enterobacteria by the Colicine Factor collJournal of General Microbiology, 1965