Stimulation of PGE2 synthesis and water and electrolyte secretion by senna anthraquinones is inhibited by indomethacin
- 12 April 1985
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 37 (4), 248-251
- https://doi.org/10.1111/j.2042-7158.1985.tb05053.x
Abstract
The effect of dried senna pod extract, containing 10% sennoside B, on colonic electrolyte and fluid transport was examined in the anaesthetized rat in-situ. Oral administration of senna pod extract dose-dependently (17.5−30 mg kg−1, calculated as sennoside B) reversed net absorption of water, sodium and chloride to net secretion and increased potassium secretion. Senna pod extract stimulated the output of prostaglandin E2 into the colonic lumen. Inhibition of prostaglandin biosynthesis by pretreatment of the rats with indomethacin (10 mg kg−1) significantly inhibited the effects of senna pod extract (17.5–30 mg kg−1) both on net fluid transport and on prostaglandin E2 synthesis. The inhibitory effect of indomethacin on net fluid transport induced by senna pod extract (30 mg kg−1) was dose-dependent. It is concluded that anthraquinones exert their laxative action at least partially via stimulation of colonic fluid and electrolyte secretion, and that this secretion is mediated by stimulation of endogenous prostaglandin E2 formation.Keywords
Funding Information
- Austrian Scientific Research Funds (4920)
This publication has 23 references indexed in Scilit:
- Prostaglandin E2 in jejunal fluids and its potential diagnostic value for selecting patients with indomethacin‐sensitive diarrhoeaEuropean Journal of Clinical Investigation, 1981
- Effect of diphenolic laxatives on Na+-K+-activated ATPase and cyclic nucleotide content of rat colon mucosa in vivoNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1980
- Effects of bisacodyl on cAMP and prostaglandin E2 contents, (Na+K) ATPase, adenyl cyclase, and phosphodiesterase activities of rat intestineDigestive Diseases and Sciences, 1980
- Metabolism of Sennosides and Rhein in the RatPharmacology, 1980
- Effect of ricinoleic acid and other laxatives on net water flux and prostaglandin E release by the rat colonJournal of Pharmacy and Pharmacology, 1979
- Is the effect of diphenolic laxatives mediated via release of prostaglandin E?Cellular and Molecular Life Sciences, 1978
- Laxative abuse.Gut, 1974
- Prostaglandin synthetase activity in the rat stomach fundus: Activation by l-norepinephrine and related compoundsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- Cathartics and the Sodium PumpNature, 1965
- Über die Wirkung des Senna-Infuses auf den Dickdarm der KatzeNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1934