Inhibition of Renal Creatinine Secretion by Cimetidine in Humans
- 1 January 1982
- journal article
- research article
- Published by S. Karger AG in Kidney and Blood Pressure Research
- Vol. 5 (1), 27-30
- https://doi.org/10.1159/000172836
Abstract
The renal clearance of inulin (Clin), 14C-creatinine (Cl14C-cr) and endogenous creatinine (Clcr) were measured in 6 healthy subjects before and after a single i.v. bolus of cimetidine (5 mg/kg). The initial Cl14C-cr/Clin ratio (mean .+-. SD) was 1.68 .+-. 0.17; this fell to a nadir of 1.35 .+-. 0.18 soon after cimetidine was infused and rose again as the drug was excreted. This is the 1st cationic drug to show substantial inhibition of tubular secretion of creatinine in humans.Keywords
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