Effect of Insulin on Rate of Hepatic Uptake of NEFA.

Abstract

Concentrations of NEFA in plasma of blood obtained from splenic artery, portal and hepatic veins were measured in un-anesthetized dogs together with hepatic plasma flow. Rates of hepatic and non-hepatic splanchnic uptake or output of NEFA were calculated before and after insulin administration. A marked increase in rate of hepatic uptake of NEFA was observed after insulin administration. No significant change in rate of NEFA output from non-hepatic splanchnie area was found.