Probing biomolecular interactions using surface enhanced Raman spectroscopy: label-free protein detection using a G-quadruplex DNA aptamer
- 2 March 2010
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 46 (16), 2799-2801
- https://doi.org/10.1039/b920941g
Abstract
We demonstrate a strategy for label-free protein detection through monitoring the Surface Enhanced Raman Spectrum of an aptamer probe attached to a gold nanoshell. Low limit of detection and minimal non-specific binding show potential for in vitro and in vivo assays.Keywords
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