EVIDENCE FROM CROSSTRANSFUSION EXPERIMENTS THAT THE DIMINISHED URINE FLOW ACCOMPANYING ISCHEMIC COMPRESSION SHOCK IS NOT DUE TO HUMORAL FACTORS

Abstract

Urine formation was measured in dogs subjected to ischemic compression trauma and in test dogs crosstransfused in pairs with these traumatized dogs. Urine flow was measured by catheterization of the bladder and collected at 15 min. intervals. No impairment of urine formation was observed in the test dogs which could be attributed to the operation of a humoral factor received from the traumatized dogs. Pairs of normal dogs were crosstransfused and other dogs traumatized alone were studied. In all of the traumatized dogs and in some of the control dogs temporary or permanent cessation of urine flow was observed. Since the cessation of urine flow occurred at the same mean arterial pressure in control and traumatized dogs it was concluded that lowering of the mean arterial pressure together with homeostatically induced renal vasoconstriction were probably sufficient to account for the cessation of urine flow in the traumatized dogs.