REACTIVITY OF ISOLATED TRACHEA, BRONCHUS AND LUNG STRIP OF CATS TO CARBACHOL, 5‐HYDROXYTRYPTAMINE AND HISTAMINE: EVIDENCE FOR THE EXISTENCE OF METHYSERGIDE‐SENSITIVE RECEPTORS
Open Access
- 1 August 1981
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 73 (4), 853-857
- https://doi.org/10.1111/j.1476-5381.1981.tb08738.x
Abstract
1 The reactivity was investigated of cat isolated tracheal chains, bronchial spirals and lung parenchymal strips to carbachol, 5-hydroxytryptamine (5-HT) and histamine. 2 Carbachol and 5-HT produced concentration-dependent contractions of all three tissues, responses to the former drug being selectively blocked by atropine and to the latter by methysergide. 3 Histamine failed to elicit a contractile response from the tracheal or bronchial muscle. However, it induced dose-related contractions of the lung strips, that were selectively blocked by mepyramine. 4 It is concluded that lung parenchymal strips of cats possess mepyramine-sensitive histamine H1-receptors. Receptors for 5-HT, susceptible to methysergide, occur in the tracheobronchial smooth muscles as well as in lung strips of cats.Keywords
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