Programmable nanomedicine: synergistic and sequential drug delivery systems
- 29 January 2015
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Nanoscale
- Vol. 7 (8), 3381-3391
- https://doi.org/10.1039/c4nr07677j
Abstract
Recent developments in nanomedicine for the cancer therapy have enabled programmable delivery of therapeutics by exploiting the stimuli-responsive properties of nanocarriers. These therapeutic systems were designed with the relevant chemical and physical properties that respond to different triggers for enhanced anticancer efficacy, including the reduced development of drug-resistance, lower therapeutic dose, site-specific transport, and spatiotemporally controlled release. This minireview discusses the current advances in programmable nanocarriers for cancer therapy with particular emphasis on synergistic and sequential drug delivery systems.Keywords
This publication has 89 references indexed in Scilit:
- Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategiesNature Reviews Drug Discovery, 2014
- Cancer Nanomedicine: From Drug Delivery to ImagingScience Translational Medicine, 2013
- Nanoparticles for Combination Drug TherapyACS Nano, 2013
- First-Line Treatment of Advanced Breast Cancer With Sunitinib in Combination With Docetaxel Versus Docetaxel Alone: Results of a Prospective, Randomized Phase III StudyJournal of Clinical Oncology, 2012
- Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to ApplicationsNano Letters, 2010
- Improving the efficacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations☆Advanced Drug Delivery Reviews, 2010
- Combination therapy: Opportunities and challenges for polymer–drug conjugates as anticancer nanomedicinesAdvanced Drug Delivery Reviews, 2009
- In vivo maintenance of synergistic cytarabine:daunorubicin ratios greatly enhances therapeutic efficacyLeukemia Research, 2009
- Nanocarriers as an emerging platform for cancer therapyNature Nanotechnology, 2007
- Designer combination therapy for cancerNature Biotechnology, 2006