THE COURSE OF BLOOD SUGAR AFTER INTRAVENOUS INSULIN IN NORMAL DOGS AND CATS

Abstract

Over a dose range of 0.1 to 2.0 units per kilo the action of intraven. insulin in the dog reflects itself nearly exclusively in duration of action. In the cat both duration and intensity of action vary with the dose. The significance of the results particularly as they relate to "glycogenolysis inhibiting action of insulin" arc discussed. Ordinary insulin for clinical use contains a blood sugar raising impurity whose existence can be clearly demonstrated in cats but not in dogs. Its action is not dependent on the adrenal. About one gamma of impurity per milligram will produce measurable effects in cats. In crystalline insulin this impurity is absent.