Anaphylactoid Reaction to Nitrofurantoin

Abstract

NITROFURANTOIN (Furadantin) has become increasingly useful in the treatment of resistant urinary-tract infections and is now widely employed. Nitrofurazone (Furacin), which is used topically in chronic skin infections, is known to be associated with frequent skin sensitivity reactions, but reactions to nitrofurantoin, other than gastrointestinal symptoms, have not been widely reported. Severe anaphylactoid reactions of the type described below are not recorded in the literature. Stewart and Rowe¹ reported 12 per cent reactions, mostly gastrointestinal, in a review of 107 patients. One patient required hospitalization for dermatitis medicamentosa, and 1 had a "slight sensation of pressure in the rectum and . . .