CSF somatostatin‐like immunoreactivity in dementia
- 1 February 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 36 (2), 294
- https://doi.org/10.1212/wnl.36.2.294
Abstract
Concentrations of somatostatin-like immunoreactivity (SLI) in CSF were reduced in Alzheimer''s disease (AD) and multi-infarct dementia (p < 0.01), but not in normal-pressure hydrocephalus, Parkinson''s disease, and Huntington''s disease. This suggests that reduced SLI content in AD cerebral cortex is reflected in CSF. Chromatographic characterizaton of CSF SLI showed no differences between AD and controls. Concentrations of SLI in AD patients overlapped those in both normal subjects and patients with multi-infarct dementia, so that changes in CSF SLI have no diagnostic specificity.This publication has 15 references indexed in Scilit:
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