Nitroarginine inhibits endothelium-derived relaxation.
- 1 January 1990
- journal article
- research article
- Published by Elsevier in The Japanese Journal of Pharmacology
- Vol. 52 (1), 167-169
- https://doi.org/10.1254/jjp.52.167
Abstract
Effects of NG-nitro-L-arginine (NO2Arg), a guanidinonitro arginine derivative, on acetylcholine-induced relaxation of rabbit thoracic aorta ring preparation were studied. Relaxation by acetylcholine was inhibited by NO2Arg dose-dependently and the maximum relaxation with 102 .mu.M NO2Arg was reduced to 10.1+4.3% (n = 5). L-arginine (10 .mu.M) did not affect the acetylcholine-induced relaxation. Relaxation by glyceryltrinitrate or papaverine was not affected by NO2Arg. These results indicate that NO2Arg is a novel inhibitor of endothelium-derived relaxation.This publication has 3 references indexed in Scilit:
- Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cellsBiochemical and Biophysical Research Communications, 1988
- L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxationBiochemical and Biophysical Research Communications, 1988
- Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.Circulation Research, 1987