The myxalamids, new antibiotics from Myxococcus xanthus (Myxobacterales) I. production, physico-chemical and biological properties, and mechanism of action.
- 1 January 1983
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 36 (9), 1150-1156
- https://doi.org/10.7164/antibiotics.36.1150
Abstract
From the cell mass and culture supernatant of M. xanthus strain Mx X12 an antibiotic activity against yeasts, molds and some gram-positive bacteria was extracted. It consisted of 4 biologically active compounds which were named myxalamid A, B, C and D. The main component, myxalamid B, blocked the respiratory chain at the site of complex I, i.e., NADH: ubiquinone oxidoreductase, in beef heart submitochondrial particles.This publication has 1 reference indexed in Scilit: