Terminal Transferase and Leukemia
- 10 April 1975
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 292 (15), 804-805
- https://doi.org/10.1056/nejm197504102921510
Abstract
Terminal deoxynucleotidyl transferase (TdT) is an enzyme that catalyzes the elongation of preformed oligomeric or polymeric DNA chains by adding deoxyribonucleoside monophosphates to the 3′-OH ends of these chains.1 It was discovered independently by Bollum and his colleagues2 , 3 and by Krakow et al.4 Two features of TdT make it a unique and interesting enzyme. The first is that, unlike any other DNA-synthesizing enzyme (DNA polymerase), it does not use nucleic acid templates for instruction. Consequently, it has no apparent biologic role in DNA replication or repair. Secondly, in a survey of many tissues, Chang showed that appreciable levels of TdT . . .Keywords
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