The Effect of Intrinsic Factor on the Absorption of Vitamin B12 in Older People
Open Access
- 1 November 1957
- journal article
- research article
- Published by Elsevier in The American Journal of Clinical Nutrition
- Vol. 5 (6), 651-658
- https://doi.org/10.1093/ajcn/5.6.651
Abstract
Determinations of the vitamin B12 level in the plasma were made on 201 persons between the ages of 37 and 92 years. A statistically significant decline in the plasma vitamin B12 level with age was found. This decline, calculated by the method of least squares, was 0.00521 mµg per ml of plasma per year of age. Schilling assays were done on twenty elderly subjects. Administration of intrinsic factor increased the urinary excretion of radioactive vitamin B12 in those who had poor vitamin B12 absorption as well as low plasma levels. On the other hand, the subjects with a urinary excretion of vitamin B12Co60 in the normal range, but with low plasma levels, did not show a statistically significant change when intrinsic factor was given in addition to vitamin B12. Thirty-eight people with low normal plasma vitamin B12 levels (0.3 to 0.5 mµg per ml) were given vitamin B12 orally for five months. There was a statistically significant increase in plasma concentration of vitamin B12. However, the increase in the amount of vitamin B12 in the plasma was just as great when intrinsic factor was given with vitamin B12 as when the subjects received vitamin B12 alone. No evidence for any inhibitory activity of the intrinsic preparations was found.Keywords
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