A stereoselective route to enantiomeric 2-alkyl-1,2,3,6-tetrahydropyridines

Abstract

A synthesis of (R)- or (S)-2-alkyl-1,2,3,6-tetrahydropyridines (1), starting from (R)- or(S)-phenylglycinol and Zincke's salt (2), and proceeding via the new oxazolidine derivative (5) as a key intermediate, is described.