EXPERIMENTAL RENAL INSUFFICIENCY PRODUCED BY PARTIAL NEPHRECTOMY

Abstract

The effect of diet on the function of the normal and the abnormal kidney has not been agreed on by experimental workers or clinicians. Reports from this laboratory have shown that renal hypertrophy, renal function, cardiac hypertrophy and blood pressure in intact and in partially nephrectomized rats are affected by diets containing varying concentrations of whole meat, extracted meat, whole liver and extracted liver. The purpose of this paper is to present a summary and comparison of these results obtained with the various diets.¹ The experimental methods and the results have been presented in detail.²The whole and the water-extracted meat and liver were dried and incorporated in balanced experimental diets. All animals chosen for these analyses were fed the experimental diets from a minimum of seventy-five to a maximum of one hundred and seventy-five days. KIDNEY WEIGHT Intact Animals. —The average kidney weight per hundred square centimeters