MACROPHAGES AS A CELLULAR EXPRESSION OF INHERITED NATURAL RESISTANCE
- 1 February 1962
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 48 (2), 160-165
- https://doi.org/10.1073/pnas.48.2.160
Abstract
Tissue cultures of peritoneal macrophages prepared from individual mice of the eighth generation of backcrossing between virus-resistant hybrids and virus-susceptible C3H mice were exposed to West Nile virus. Half of the cultures failed to support virus multiplication, while the remaining cultures yielded infectious virus. This distribution of resistance and susceptibility in macrophage culture reflected, on the cellular level, genes segregating for virus resistance and susceptibility on the whole animal level.Keywords
This publication has 4 references indexed in Scilit:
- MOUSE MACROPHAGES AS HOST CELLS FOR THE MOUSE HEPATITIS VIRUS AND THE GENETIC BASIS OF THEIR SUSCEPTIBILITYProceedings of the National Academy of Sciences, 1960
- BEHAVIOR INVITRO OF A MOUSE LYMPHOID-LEUKEMIA VIRUS1960
- Mechanism of natural resistance of mice to virus infectionVirology, 1959
- Techniques for Hemagglutination and Hemagglutination-Inhibition with Arthropod-Borne VirusesThe American Journal of Tropical Medicine and Hygiene, 1958