ASSAY OF SUXAMETHONIUM AND LAUDEXIUM ON THE FROG RECTUS ABDOMINIS
Open Access
- 1 June 1959
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 14 (2), 158-163
- https://doi.org/10.1111/j.1476-5381.1959.tb01376.x
Abstract
Suxamethonium, like acetylcholine, causes contracture of the isolated rectus abdominis muscle of the frog, whereas laudexium antagonizes this effect. These actions may be used to assay both drugs with reasonable speed and fiducial limits, provided that changes in responsiveness of the preparation during the course of assay are met by suitable design and analysis. Small quantities of suxamethonium and laudexium may be assayed in certain body fluids.Keywords
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