Clinical Syndrome of Variant Angina with Normal Coronary Arteriogram

Abstract

We compared patients with variant angina (ST-segment elevation during pain) who had normal or near normal coronary arteriograms (Group 1) with 20 in whom variant angina occurred in the presence of obstructive coronary lesions (Group 2). A long history of nonexertional angina without angina of effort or previous infarction was the rule in Group 1, whereas recent-onset unstable angina preceded by effort angina and infarction predominated in Group 2 (P<0.001). Normal electrocardiograms at rest, with ischemic ST-segment elevation in the inferior leads, and ischemia-induced heart block and bradycardia, characterized Group 1, whereas abnormal electrocardiograms, ischemic involvement of anterolateral leads and ventricular tachycardia or fibrillation were more common in Group 2 (P<0.001). Variant angina with normal coronary arteriogram generally has a benign course and is probably unrelated to atherosclerosis. (N Engl J Med 295:1343–1347, 1976)