Excluding circumscribed nevi, probably no congenital developmental anomalies of the skin are more common than the multitudinous gradations of ichthyosis, varying from the xerodermatous type of skin, that is merely somewhat dry and scaly, to the keratotic armor of the fetus at birth. Somewhat rare, however, are cases of ichthyosis accompanied by the formation of small and large bullae. Of this type I have observed two unusually interesting cases during the last four years. REPORT OF CASES Case 1.— A woman, aged 32, had had a cutaneous disease since birth. The skin of the entire body was harsh, dry and thick, and large scales were freely exfoliated. She did not perspire in the ordinary manner when exerting herself, or in rather hot weather without exertion. Bullae varying in size from 1 to 2.5 cm. appeared abundantly on the skin everywhere (fig. 1). When the bullae disappeared, and evidently they did