BIOLOGICAL DIFFERENCES IN RESPONSE OF THE FEMALE MACACUS MONKEY TO EXTRACTS OF THE ANTERIOR PITUITARY AND OF HUMAN PREGNANCY URINE

Abstract

The gonad stimulating hormone of the anterior pituitary causes follicular activation of the monkey ovary. This induced follicular activation causes reddening of the sex skin accompanied by turgosity and pachydermatous foldings. Such changes of the sex skin can be obtained by a slight amount of estrin (E. Allen). The use of extracts of human pregnancy urine which activates the gonad of rats causes no follicular stimulation in the monkey, as judged either by the response of the sex skin or by histological study. Instead, all follicular activity is stopped and all small and medium sized follicles become hyalinized. Typical corpora lutea are not formed with this extract by any method in these animals. The report includes observations on 37 1800-5150-gm. monkeys. The period of treatment was 9-32 days.