Rat malarial glomerulonephritis
- 1 December 1981
- journal article
- research article
- Published by Springer Nature in Virchows Archiv B Cell Pathology Including Molecular Pathology
- Vol. 37 (1), 343-356
- https://doi.org/10.1007/bf02892583
Abstract
This paper describes the immunopathologic findings in acute malaria-associated glomerulonephritis in the rat. Young Sprague-Dawley rats were infected withPlasmodium berghei berghei. The subsequent parasitemia and elevation of circulating Clq-reactive immune complexes were transient while the appearance of anti-plasmodial antibody in the serum was persistent. Sequential examination of renal tissue and urine revealed the following glomerular alterations: (a) granular, predominantly mesangial deposits of IgG, IgM, and C 3, (b) electron dense deposits in the mesangial matrix, (c) glomerular deposition of plasmodial antigen(s) and of anti-plasmodial antibody as demonstrated by acid elution studies, (d) hypercellularity of the glomerular tufts and (e) increased urinary excretion of high molecular weight proteins. All renal abnormalities were transitory, disappearing within one to three months. The results indicate that this form of acute malarial glomerulonephritis in rats is mediated by immune complexes involving plasmodial antigen. The disease resembles the transient glomerular injury complicating cases ofPlasmodium falciparum infection in humans. As an easily reproducible model, rat malarial glomerulonephritis appears most suitable for further immunopathologic and functional studies of post-infectious glomerular disease.Keywords
This publication has 20 references indexed in Scilit:
- Studies on the Pathogenesis of Aleutian Disease of MinkZentralblatt für Veterinärmedizin Reihe B, 1980
- In situ immune complex formation and glomerular injuryKidney International, 1980
- Immunologic aspects of renal lesions associated with malariaKidney International, 1979
- Experimental nephritis associated with plasmodium infection in miceKidney International, 1979
- Das nephrotische Syndrom beim ErwachsenenDeutsche Medizinische Wochenschrift (1946), 1975
- Plasmodium berghei: Experimental rodent model for malarial renal immunopathologyExperimental Parasitology, 1974
- Quartan Malarial Nephrotic SyndromeNephron, 1973
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970
- IMMUNE COMPLEXES IN THE NEPHROTIC SYNDROME OF AFRICAN CHILDRENThe Lancet, 1969
- A RAPID AND PRECISE METHOD FOR THE DETERMINATION OF UREAJournal of Clinical Pathology, 1960