Abstract
Nicotine reduces the amplitude of the fertilization potential in sea urchin eggs, at least partly because it decreases the slope of the current voltage relation of the unfertilized egg membrane. The reduced fertilization potential amplitude provides an electrophysiological explanation for previous observations that nicotine impairs the fast block to polyspermy. The block to polyspermy is impaired by fertilization in low Na sea water, a medium which reportedly reduced fertilization potential amplitude.