Serial cytogenetic studies of human colonic tumour xenografts
Open Access
- 1 April 1978
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 37 (4), 612-619
- https://doi.org/10.1038/bjc.1978.91
Abstract
Chromosome studies have been made of 2 human colonic tumour lines maintained as xenografts in immune-deprived mice. In both tumours human karyotypes were retained, although progressive changes occurred during serial passage. In one tumour, independent gain of a chromosome 19 was found in the stemline and 2 sidelines. In the other tumour there was selection for a sideline containing a particular deleted marker chromosome. The advantages of chromosome analysis in a xenograft system, both for the study of human solid tumour karyotypes and for monitoring the continued presence of the human genome, are discussed.Keywords
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