The analysis of a titration study

Abstract

For analysis of data from a titration study, this paper adopts the idea of a life table analysis and utilizes a logistic linear dose–response model. The procedure uses iterated reweighted least-squares to provide parameter estimates. Computation of the asymptotic covariance of the life-table estimates of the response rates involves Greenwood's formula and a conditioning argument. A special case consists of examination of the covariance structure when no dropouts took place. Data from a titration study that investigated the efficacy of an anti-hypertensive compound illustrate the procedure.