Effects of Cortisone and Epinephrine Exhibition on Lipid Components and Phospholipid Turnover in Plasma, Liver and Aorta of Rabbits

Abstract

Concentrations of lipid components and the incorporation of radioactive P (p32) in the plasma, liver, and aorta of rabbits treated for 14 consecutive days with single daily injections of epinephrine (intravenously, 0.05 mg/kg), cortisone (intramuscularly, 10 mg), cortisone and epinephrine, and control rabbits were measured. Markedly altered concentrations of lipid fractions in plasma and liver were found in those animals which had received cortisone (alone and in conjunction with epinephrine) and the phospho-lipids in plasma and liver were synthesized several times faster than in controls. But cortisone exhibition did not change the concentrations of aortic lipid fractions nor phospholipid turnover in that organ. Epinephrine exhibition resulted in moderate changes in plasma lipid relationships and an increased incorporation of P32 in the aorta was found.