Differential Expression of IRS‐1 and IRS‐2 in UterineLeiomyosarcomas with Distinct Oncogenic Phenotypes: Lack ofCorrelation with Downstream Signaling Events
Open Access
- 1 January 2000
- Vol. 6 (3), 89-96
- https://doi.org/10.1080/1357714021000065387
Abstract
Purpose: Insulin receptor substrates (IRSs) are essential for insulin-induced mitogenic effects on several cell types but they also are involved in cell transformation.We investigated whether the differential constitutive expression and potential distinct downstream signaling events of IRS-1 and IRS-2 might be related to discrete tumourigenic phenotypes of three human uterine leiomyosarcoma cell lines, one of which was specifically isolated for the present study.Keywords
Funding Information
- Ministero dell'Università della Ricerca (FSN-1999, Co?fin 1999)
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