Effects of Positive End-expiratory Pressure on Gas Exchange in Dogs with Normal and Edematous Lungs

Abstract

The effects of positive end-expiratory pressure (PEEP) at 5, 10, 15 and 20 cm H2O on the distribution of ventilation-perfusion (.ovrhdot.VA/.ovrhdot.Q) ratios was determined in 4 normal dogs and in 10 with oleic acid-induced acute hemorrhagic pulmonary edema. Tidal volume and frequency were held constant at all times with mechanical ventilation during i.v. pentobarbital and gallamine anesthesia. Normal dogs had little or no shunt, and no areas of low (< 0.1) or high .ovrhdot.VA/.ovrhdot.Q (> 10.0) at zero end-expiratory pressure (intermittent positive-pressure breathing). In these animals increasing PEEP caused progressive depression of cardiac output, associated with an increase in ventilation to both high .ovrhdot.VA/.ovrhdot.Q and unperfused regions. PEEP .gtoreq. 10 cm H2O resulted in a reduction in PaO2 [arterial partial pressure of O2] and an increase in PaCO2. In dogs with pulmonary edema, PEEP of 5 and 10 cm H2O resulted in dramatic reductions in shunt, virtual obliteration of low .ovrhdot.VA/.ovrhdot.Q regions and marked improvement in PaO2. At 15 and 20 cm H2O PEEP, high .ovrhdot.VA/.ovrhdot.Q and dead space ventilation with CO2 retention again developed in all but the most severely affected (shunt > 40%) dogs.