IMMUNOLOGICAL AND BIOCHEMICAL COMPARISON OF STREPTOKINASE AND STREPTOKINASE PLASMINOGEN COMPLEX

Abstract

Biochemcial and immunological studies were made on streptokinase [used therapeutically as a plasminogen activator] and its 1:1 molar complex with [human] plasminogen. The complex was not recognized by antibodies to streptokinase. The potential of using this complex in vivo to avoid the febrile response seen with streptokinase alone was considered.