On the basis of previous investigations showing the antiepileptic action of taurine in both acute and chronic experimental epileptogenic foci, taurine was administered intraperitoneally to 15 highly refractory patients presenting daily frequent seizures of various types. Taurine was given daily for the first 10 days and weekly during the subsequent 50-day period. In most subjects seizures disappeared and the EEG improved during the first period, while a progressive relapse to pre-taurine conditions occurred during the second period. Only in four young patients (two HHE syndromes and two primary generalized epilepsies) improvement persisted up to the end of the follow-up period. This result, besides any theoretical speculations (taurine non-specific action?), may commend use for the taurine treatment in refractory young patients having frequent seizures.