Endopeptidases in the Brush Border of the Kidney Proximal Tubule
- 1 January 1977
- book chapter
- Published by Wiley
- No. 50,p. 209-220
- https://doi.org/10.1002/9780470720318.ch12
Abstract
Among the five peptidases known to be located in the microvillus membrane of the renal proximal tubule are two enzymes with endopeptidase activity. Neutral endopeptidase, a zinc-dependent enzyme, has a broad specificity comparable to that of thermolysin, and like the latter may be specifically inhibited by phosphoramidon. Dipeptidyl peptidase IV, a serine enzyme, is very sensitive to inhibition by diisopropyl phosphorofluoridate. It is also capable of endopeptidase activity, hydrolysing bonds involving the carboxyl group of proline.Keywords
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