Chromosomal localization of group-specific component by in situ hybridization

Abstract

Group-specific component (GC), an alpha2-globulin plasma protein synthesized primarily in the liver, is the major vitamin D-binding protein in plasma. It has two common phenotypes, GC1 and GC2, which appear in all human populations. Using the cDNA insert containing the entire coding sequence of GC2, the GC gene was mapped to human chromosomal bands 4q13→q21.1 by in situ hybridization.