INTERACTION BETWEEN QUERCETIN AND CA-2+-CALMODULIN COMPLEX - POSSIBLE MECHANISM FOR ANTI-TUMOR-PROMOTING ACTION OF THE FLAVONOID
- 1 January 1984
- journal article
- research article
- Vol. 75 (4), 311-316
Abstract
Quercetin has similar inhibitory effects on tumor promoter-induced phenomena [in chick fibroblasts and human HeLa cervical carcinoma cells] as N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist. Quercetin interacts directly with the Ca2+-calmodulin complex. Quercetin may act as a calmodulin antagonist, and its antagonistic effect on calmodulin may be important in its anti-tumor-promoting action in vivo.This publication has 4 references indexed in Scilit:
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