Studies of Mycobacterium tuberculosis H37Rv Grown in vivo: Inhibitor of Lactic Acid Dehydrogenase in Normal and Infected Mice

Abstract

Various organs of tuberculous and normal mice contain a substance which inhibits lactic dehydrogenase in cell-free extracts of Mycobacterium phlei. Evidence is presented that the tuberculous process is accompanied by a pronounced increase in the inhibitory activity of the various organs as compared with that of corresponding organs from normal mice. These data also indicate that host tissue is the origin of the inhibitor previously found on tubercle bacilli grown in vivo.