Increased Cholesterol Biosynthesis Following Phenobarbital Induced Hypertrophy of Agranular Endoplasmic Reticulum in Liver.

Abstract

Summary Previous workers have correlated hypertrophy of the agranular reticulum in the liver with increase in drug-metabolizing enzymes following repeated injections of phenobarbital. Our investigation confirms their morphological observation and adds additional biochemical data which suggest that the enzyme systems responsible for cholesterol biosynthesis are associated with the smooth reticulum and are also increased following phenobarbital stimulation.