Adult polycystic kidney disease and linked RFLPs at the alpha globin locus: a genetic study in the South Wales population.
Open Access
- 31 July 1987
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 24 (8), 466-473
- https://doi.org/10.1136/jmg.24.8.466
Abstract
Thirteen South Wales kindreds with adult polycystic kidney disease have been studied for genetic linkage using the alpha globin and 3'HVR probes. A maximum lod score of 24.187 was found at a recombination fraction of 0.03. This study supports the existence of a single locus on chromosome 16 responsible for the disorder.This publication has 15 references indexed in Scilit:
- Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16.BMJ, 1986
- A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16Nature, 1985
- Direct cloning of specific genomic DNA sequences in plasmid libraries following fragment enrichmentNucleic Acids Research, 1985
- Prognosis of adult onset polycystic kidney disease re-evaluatedKidney International, 1984
- Strategies for multilocus linkage analysis in humans.Proceedings of the National Academy of Sciences, 1984
- Age at clinical onset and at ultrasonographic detection of adult polycystic kidney disease: Data for genetic counsellingAmerican Journal of Medical Genetics, 1984
- Cystic kidneysHuman Genetics, 1984
- Potential Causes and Pathogenesis in Autosomal Dominant Polycystic Kidney DiseaseNephron, 1983
- Polycystic kidney diseaseKidney International, 1982
- BILATERAL POLYCYSTIC DISEASE OF THE KIDNEYSThe American Journal of the Medical Sciences, 1959