Regioselective Preparation of 4-Formyl-3,5-dimethoxyphenol, an Intermediate in the Synthesis of the PAL Solid-Phase Peptide Synthesis Handle

1 January 1991

journal article
research article
Published by Taylor & Francis in Synthetic Communications

Vol. 21 (2), 167-171
https://doi.org/10.1080/00397919108020808

Abstract

An improved procedure for preparation of 4-formyl-3,5-dimethoxyphenol is reported. The principal advantages of the new procedure over previous preparations are complete regioselectivity and higher yield.

Keywords

This publication has 3 references indexed in Scilit:

Preparation and application of the 5-(4-(9-fluorenylmethyloxycarbonyl)aminomethyl-3,5-dimethoxyphenoxy)-valeric acid (PAL) handle for the solid-phase synthesis of C-terminal peptide amides under mild conditions
The Journal of Organic Chemistry, 1990
Regioselectivity in lithiation of t-butyldimethylsiloxy-3, 5-dimethoxybenzene. A synthesis of the trimethyl ether of sophoraflavanone A
Tetrahedron Letters, 1985
The triisopropylsilyl group as a hydroxyl-protecting function
The Journal of Organic Chemistry, 1980

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