Short-Term Radioprotective Effects of WR-2721 on the Rat Parotid Glands
- 1 August 1978
- journal article
- research article
- Published by JSTOR in Radiation Research
- Vol. 75 (2), 317-326
- https://doi.org/10.2307/3574907
Abstract
The radioprotective capacity of the chemoprotector WR-2721 [S-2-(3-aminopropyl amino)-ethylphosphorothioic acid] was assessed in the rat parotid gland using gland weight and amylase content as the indicators of effect over the 9-day period following X-irradiation with 1.6, 3.2 and 6.4 kR of acute X-rays. The decline and recovery of weights and amylase content were measured and compared in animals which had and had not received WR-2721 just prior to irradiation. Analysis of the dose-response curves for the WR-2721 protected vs. nonprotected animals yielded dose modification factors of 2.5 for gland weight, 1.7 for amylase concentration and 1.8 for total gland amylase. WR-2721 was effective in yet another tissue and to a degree consistent with that of other organs and systems.This publication has 5 references indexed in Scilit:
- Biochemical changes in rat parotid gland lysosomal enzyme activities after isoprenaline or starvationArchives of Oral Biology, 1977
- Effects of X-irradiation and the resultant inanition on amylase content of the rat parotid glandArchives of Oral Biology, 1977
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- Enzymes of Starch Degradation and SynthesisPublished by Wiley ,1951