The effect of additives on the oral mucosal absorption of human calcitonin in rats.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in Journal of Pharmacobio-Dynamics
- Vol. 11 (6), 395-401
- https://doi.org/10.1248/bpb1978.11.395
Abstract
The oral mucosal absorption of human calcitonin (HCT) was investigated in rats. Enhanced absorption of HCT was observed by coadministration of additives such as sodium deoxycholate, sodium tauroglycocholate, quillajasaponin (Quillayanin P-20), sodium lauryl sulfate, sodium myristate and sugar esters. The contribution of sugar ester having a hydrophilic-lipophilic balance value between 11 to 16 was found to be effective in increasing the absorption of HCT. Furthermore, it suggested that the type of constituent fatty acid of sugar ester was one of several important factors for the promotion of the oral mucosal absorption of HCT.This publication has 5 references indexed in Scilit:
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